Published 1983 | Version v1
Journal article Metadata-only

An experimental study on radon 222 carcinogenesis. A comparison with epidemiological surveys

Creators

  • 1. COGEMA, Division de la Crouzille, Razes (France)
  • 2. Centre d'Etudes de Bruyeres-le-Chatel (CEB III), Montrouge (France)
  • 3. Commissariat a l'Energie Atomique, IPSN, Fontenay-aux-Roses (France)

Description

For over ten years, investigations have been carried out at the French Commissariat a l'Energie Atomique in order to measure in the rat the carcinogenic action of radon 222 daughter products. The results allow to define a dose-effect relationship for doses ranging from 60 to 8000 WLM (working level month). These results can be compared with those supplied by epidemiological surveys conducted on various populations of uranium miners. The effects of various parameters such as dose-rate, dose protraction and age of the animals at exposure are also analyzed. At last, the effects of various co-factors including cigarette smoke are studied. The results show that animal investigation makes it possible to extrapolate to man for doses lower than those for which results of epidemiological surveys are available

Abstract (French)

Depuis plus de dix ans, des experiences ont ete pratiquees au CEA pour mesurer, chez le rat, l'action cancerigene des produits de filiation du radon 222. Les resultats obtenus permettent de definir une relation dose-effet pour des doses comprises entre 60 et 8000 WLM (working level month). Ces resultats sont comparables a ceux fournis par les enquetes epidemiologiques pratiquees sur diverses populations de mineurs d'uranium. On analyse, de plus, l'action de parametres tels que le debit de dose, l'etalement de la dose et l'age des animaux au moment de l'irradiation. Enfin, on etudie l'action de divers cofacteurs dont la fumee de cigarettes. Les resultats montrent que l'experimentation animale permettra d'extrapoler les effets chez l'homme pour des doses plus faibles que celles pour lesquelles on possede deja des resultats d'enquetes epidemiologiques

Additional details

Additional titles

Original title (French)
Etude experimentale de l'action cancerigene du radon 222. Comparaison avec les etudes epidemiologiques

Publishing Information

Journal Title
Radioprotection
Journal Volume
18
Journal Issue
2
Series
Radioprotection.
Journal Page Range
95-105
ISSN
0033-8451

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
15001701
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; CARCINOMAS; CEA; DAUGHTER PRODUCTS; DOSE RATES; DOSE-RESPONSE RELATIONSHIPS; EPIDEMIOLOGY; INHALATION; LATENCY PERIOD; LUNGS; RADON 222; RATS; TOBACCO SMOKES
Descriptors DEC
AEROSOLS; ALPHA DECAY RADIOISOTOPES; ANIMALS; BIOLOGICAL EFFECTS; BODY; COLLOIDS; DAYS LIVING RADIOISOTOPES; DISEASES; DISPERSIONS; EVEN-EVEN NUCLEI; FRENCH ORGANIZATIONS; HEAVY NUCLEI; INTAKE; ISOTOPES; MAMMALS; NATIONAL ORGANIZATIONS; NEOPLASMS; NUCLEI; ORGANS; RADIATION EFFECTS; RADIOISOTOPES; RADON ISOTOPES; RESIDUES; RESPIRATORY SYSTEM; RODENTS; SMOKES; SOLS; VERTEBRATES