Assessment of regional wall-motion abnormalities with phase-matched dual-energy DSA

This paper reports on the evaluation of regional wall-motion abnormalities (RWMAs) which plays a clinically significant role in the assessment and management of coronary artery disease. To avoid the problems of changing coordinate systems in traditional end-diastole (ED)/end-systole (ES) techniques, a phase-matched technique, which compares images of the same cardiac phase before and after intervention, is being studied. ED-DSA was used to acquire intravenous ventribulograms at control and varying levels of myocardial ischemia. Regional contractile function, reflected by systolic normalized-wall-thickening-rate (NWTR), was measured with use of transmural ultrasonic crystals in 10 dogs. Images displaying changes in systolic function were created by subtracting ES images at each level of ischemia from an ES control image