The ⁹⁹Mo/^99mTc radioisotope generator performance with radioactivity ⁹⁹Mo 600 and 800 mCi base on PZC

Radioisotope of ^99mTc has half life 6 hours, emit mono-energy gamma ray (140 KeV), easily form complex compound with various kits, and does not emit beta particle. The ^99mTc represent ideal radionuclide for diagnosis in health field compared to other radionuclides. More than 80% of the diagnosis in nuclear medicine uses the radionuclide and there are about 9 million procedures for diagnosis all over the world. Some types of generator of ⁹⁹Mo/^99mTc have been developed and commercially used. In the extraction system using Methyl Ethyl Keton (MEK), the produced ^99mTc was contaminated MEK, while in chromatography using alumina, the absorbent capacity of alumina for ⁹⁹Mo is small, and can be used for ⁹⁹Mo fission product only. Generators using gel of Zr-Mo or Ti-Mo are not reproducible. The generator system developed recently was generator using Polymer Zirconium Compound (PZC) as the adsorbent. PZC have absorption capacities for ⁹⁹Mo, and can be used for ⁹⁹Mo from (n,γ) reaction. The cost of the generator is relatively low, the technology is not complicated and the process is relatively simple. Generator system of ^99mTc based on PZC have been studied intensively including elution profile of ^99mTc using saline solution, absorption capacity of PZC for ⁹⁹Mo, radionuclide impurities in ^99mTc and stability of PZC. However, the radioactivity of ⁹⁹Mo used is still relatively low (maximum 272 mCi), while in ⁹⁹Mo/^99mTc generator, the radioactivity of ⁹⁹Mo is in the range of 300 mCi to 1000 mCi ⁹⁹Mo. In this research, the experiment of generators with high radioactivity of ⁹⁹Mo (600 up to 800 mCi) was carried out. his research aim to to know performance of the PZC column if using ⁹⁹Mo radioactivity of 600 mCi and 800 mCi. In this experiment, ^99mTc with radioactivity of 243.86 mCi and 308.59 mCi was obtained. The impurity of ⁹⁹Mo break through were 1.87 x 10-2 and 1.32 x 10-2 μCi ⁹⁹Mo/ mCi ^99mTc. The matrix of ⁹⁹Mo-PZC have small size, in the range of 0.456 to 0.583 μm, yield of ^99mTc are 116,8 % nd 56,3 %. (author)