Published 2007 | Version v1
Miscellaneous Metadata-only

Study of the production of 177Lu through 176Yb (n, γ) 177Yb → 177Lu nuclear reaction

Creators

  • 1. Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

Description

The beta minus emitter 177Lu is a promising therapeutic radioisotope for the curative treatment of cancer using labelled proteins. It has a half - life of T1/2 = 6.71 day and maximum and average β- energies of 421 and 133 keV, resulting in a short range of radiation in tissue. The decay is accompanied by the emission of low energy γ-radiation with 208.3 keV (11%) and 113 keV (6.4%) suitable for simultaneous imaging, 177Lu can be produced by two different routes, namely, by irradiation of natural Lu2O3 target (176Lu, 2.6%) or enriched (in 176Lu) Lu2O3 target, as also by irradiation of Yb target (Yb2O3) followed by radiochemical separation of 177Lu from Yb isotopes. The objective of this work is to study the production of 177Lu through the indirect 176Yb(n,γ)177Yb → 177Lu nuclear reaction. The results of the production yield of 177Lu will be shown and compared with the direct reaction. The method of choice for the chemical separation between Lu and Yb was the ion exchange, using an cation exchange resin in Cl- form and α-HIBA as eluent. Preliminary results showed a good separation of 177Lu from Yb2O3 indirect targets. (author)

Part of:
Proceedings of the INAC 2007 International nuclear atlantic conference. Nuclear energy and energetic challenges for 21st. century. 15. Brazilian national meeting on reactor physics and thermal hydraulics; 8. Brazilian national meeting on nuclear applications

Additional details

Publishing Information

ISBN
978-85-99141-02-1
Imprint Title
Proceedings of the INAC 2007 International nuclear atlantic conference. Nuclear energy and energetic challenges for 21st. century. 15. Brazilian national meeting on reactor physics and thermal hydraulics; 8. Brazilian national meeting on nuclear applications
Imprint Pagination
[vp.]
Journal Page Range
[6 p.]

Conference

Title
INAC 2007 International nuclear atlantic conference. Nuclear energy and energetic challenges for 21st. century. 15. Brazilian national meeting on reactor physics and thermal hydraulics; 8. Brazilian national meeting on nuclear applications
Dates
30 Sep - 5 Oct 2007
Place
Santos, SP (Brazil)

INIS

Country of Publication
Brazil
Country of Input or Organization
Brazil
INIS RN
38111735
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S07: ISOTOPES AND RADIATION SOURCES;
Resource subtype / Literary indicator
Conference, Numerical Data, Non-conventional Literature
Descriptors DEI
ACTIVITY LEVELS; ELUTRIATION; EXPERIMENTAL DATA; IMPURITIES; ION EXCHANGE; ISOTOPE PRODUCTION; LUTETIUM 176; LUTETIUM 177; NUCLEAR REACTIONS; YTTERBIUM 175; YTTERBIUM 176 TARGET; YTTERBIUM 177
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DATA; DAYS LIVING RADIOISOTOPES; EVEN-ODD NUCLEI; HOURS LIVING RADIOISOTOPES; INFORMATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LUTETIUM ISOTOPES; MILLISECONDS LIVING RADIOISOTOPES; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; RADIOISOTOPES; RARE EARTH NUCLEI; SECONDS LIVING RADIOISOTOPES; SEPARATION PROCESSES; TARGETS; YEARS LIVING RADIOISOTOPES; YTTERBIUM ISOTOPES

Optional Information

Notes
4 refs., 3 figs., 2 tabs. Code: E08_765.pdf