Published September 1987
| Version v1
Journal article
Macrophages specifically regulate the concentration of their own growth factor in the circulation
Creators
- 1. Albert Einstein College of Medicine, Bronx, NY (USA)
Description
The physiological mechanism of clearance of the mononuclear phagocyte growth factor, colony-stimulating factor 1 (CSF-1), from the circulation of normal mice was investigated by following the fate of a trace amount of i.v. injected 125I-labeled CSF-1. Macrophages selectively cleared CSF-1 by CSF-1 receptor-mediated endocytosis and degraded the growth factor intracellularly. This manner of clearance provides a feedback control mechanism whereby the rate of macrophage production is determined by the number of mature macrophages
Additional details
Publishing Information
- Journal Title
- Proc. Natl. Acad. Sci. U.S.A
- Journal Volume
- 84
- Journal Issue
- 17
- Series
- Proc. Natl. Acad. Sci. U.S.A.
- Journal Page Range
- 6179-6183
- ISSN
- 0027-8424
- CODEN
- PNASA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 19077677
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- AUTORADIOGRAPHY; BIOCHEMISTRY; BLOOD CIRCULATION; BLOOD-PLASMA CLEARANCE; GLYCOPROTEINS; GROWTH; IODINE 125; LABELLED COMPOUNDS; LIVER; LIVER CELLS; MACROPHAGES; MICE; PHAGOCYTOSIS
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CHEMISTRY; CLEARANCE; CONNECTIVE TISSUE CELLS; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; ELECTRON CAPTURE RADIOISOTOPES; GLANDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PHAGOCYTES; PROTEINS; RADIOISOTOPES; RODENTS; SACCHARIDES; SOMATIC CELLS; VERTEBRATES