Optimization of the time dose distribution by proliferation kinetics studies of solid Ehrlich carcinomas in AB mice after radiation exposure

Based on proliferation kinetic studies by means of autoradiography the effect of single irradiation on solid Ehrlich carcinomas is described with respect to changes in the cyclic phases. Optimum irradiation intervals of 24 hours have been derived from studies of the course of the mitotic index and from determining the radiosensitivity of the cyclic phases. This result does not agree with own investigations of the effects of different fractionation patterns on the same tumour model. It is concluded that for the success of radiation therapy proliferation kinetics of the euoxic tumour part is subordinated to the portion and inflow of hypoxic cells. (author)