Published February 1982 | Version v1
Journal article Metadata-only

The extent of bonding of newly synthesized DNA to parent template in unirradiated cells as a prediction of radiation sensitivity

Creators

  • 1. Hammersmith Hospital, London (UK). M.R.C. Cyclotron Unit
  • 2. Hammersmith Hospital, London (UK)
  • 3. Kennedy Inst., London (UK)

Description

The nature of newly synthesized DNA in several mammalian cell lines has been investigated by hydroxylapatite chromatography. By measuring the extent of bonding between newly synthesized DNA and parent DNA in unirradiated cells it is possible to predict the relative radiation sensitivity of the cell lines. The extent of bonding is inversely proportional to the radiation sensitivity of the cell lines. (author)

Additional details

Publishing Information

Journal Title
Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med.
Journal Volume
41
Journal Issue
2
Series
Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med.
Journal Page Range
193-196
ISSN
0020-7616

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
13674718
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ANIMAL CELLS; ANIONS; APATITES; DNA; HYDROXIDES; IN VITRO; ION EXCHANGE CHROMATOGRAPHY; MAMMALS; RADIOSENSITIVITY; RESPONSE MODIFYING FACTORS
Descriptors DEC
ANIMALS; CHARGED PARTICLES; CHROMATOGRAPHY; HYDROGEN COMPOUNDS; IONS; MINERALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; OXYGEN COMPOUNDS; SEPARATION PROCESSES; VERTEBRATES