Molecular mechanisms and reasons of radiation antagonism, self-induced radioprotective effect and hormesis at combined action of ionizing radiation and free radicals on DNA

The time-dependent dynamics of formation, relaxation and auto-reparation of double breaks of DNA macromolecules at the combine radiation action and non-tradition processes of degradation were considered. The auto-repairing of DNA double breaks is connected with the peculiarities of long-range interaction of nucleotide charges, atoms and molecules in the intracellular milieu. On the base of the analysis and correlation of these processes the time-dependent theory for DNA degradation was created, including hormesis phenomenon, radiation antagonism, the validity of anomaly influence of low and large doses at sharp and chronic radiation and others effects