Published July 1984
| Version v1
Journal article
Carrier-added and no-carrier-added syntheses of [18F]spiroperidol and [18F]haloperidol
- 1. Washington Univ., St. Louis, MO (USA). Edward Mallinckrodt Inst. of Radiology
Description
Syntheses of [18F]haloperidol and [18F]spiroperidol in both no-carrier-added and carrier-added forms have been accomplished. The no-carrier-added [18F]butyrophenone neuroleptics were prepared in low (<2%) yield by acid decomposition of aryl piperidine triazenes. Carrier-added 18F-neuroleptics were prepared in better (5-17%) yields by 18F-for-19F nucleophilic aromatic substitution. The preparation of all synthetic precursors, and procedures for radiolabeling are fully described. (author)
Additional details
Publishing Information
- Journal Title
- Int. J. Appl. Radiat. Isot.
- Journal Volume
- 35
- Journal Issue
- 7
- Series
- Int. J. Appl. Radiat. Isot.
- Journal Page Range
- 591-598
- ISSN
- 0020-708X
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 15069440
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- AROMATICS; CARRIER-FREE ISOTOPES; CHEMICAL PREPARATION; CHEMICAL REACTION YIELD; DECOMPOSITION; DOPAMINE; FLUORINE 18; KETONES; LIQUID COLUMN CHROMATOGRAPHY; PH VALUE; PIPERIDINES; RADIOPHARMACEUTICALS; SYMPATHOMIMETICS; TRIAZINES
- Descriptors DEC
- AMINES; AUTONOMIC NERVOUS SYSTEM AGENT; AZINES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARDIOTONICS; CARDIOVASCULAR AGENTS; CHEMICAL REACTIONS; CHROMATOGRAPHY; DRUGS; FLUORINE ISOTOPES; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NEUROREGULATORS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PHENOLS; POLYPHENOLS; PYRIDINES; RADIOACTIVE MATERIALS; RADIOISOTOPES; SEPARATION PROCESSES; STEROIDS; SYNTHESIS