Experimental study of left gastric arterial embolization with mitomycin C gelatin microspheres

Objective: To offer the theoretical evidence for clinical application, the authors observed the changes of angiographic appearances and local pathological changes before and after embolizing the left gastric artery with mitomycin C gelatin microspheres (MMC-MS). Methods: Catheter was delivered into the left gastric arteries via femoral artery and then infused MMC-MS. The angiographic appearances and local pathological changes were observed immediately, and then with follow up of 6-8 h, 24h, 72h, 1w, 2w and 4w. Results: The minute arterioles of tunic mucosa and tela submucosa were mainly embolized inducing edema and focal necrosis. With the degradation of MMC-MS, the damage of gastric tissue was alleviated but turned normal after 4 weeks. The results of DSA showed that no recanalization of the embolized vessels occurred after one week of embolization but revealed one recanalization after two weeks and two in four weeks. Conclusions: The damage of tissue induced by embolizing the left gastric artery with MMC-MS can be recovered. The application of the MMC-MS is feasible