Occurrence of parabens in outdoor environments: Implications for human exposure assessment

Highlights: • Parabens were frequently detected in outdoor air and soil samples. • Parabens had not reached equilibrium between gas phase and particle phase. • Parabens pollution in soil was obviously influenced by anthropogenic activities. • EDIs through inhalation and soil ingestion were much lower than the DAIs. • EDIs of all external exposure routes were not consistent with internal exposure. Parabens (PBs) are widely used as preservatives in food, pharmaceuticals and personal care products (PCPs). Due to their potential characteristics, similar to endocrine-disrupting compounds, their safety in our daily products and frequent exposure to human health have become public concerns. Nevertheless, little information is available about the occurrence of PBs in outdoor environments and their implications for human exposure. In this study, seven pairs of gas- and particle-phase air samples and 48 soil samples from Harbin City, China, were collected for the analysis of eight typical PBs (including methyl-paraben, ethyl-paraben, propyl-paraben, isopropyl-paraben, butyl-paraben, isobutyl-paraben, benzyl-paraben, and heptyl-paraben), which have been frequently selected as target compounds in previous studies. Concentrations of ∑₈PBs in outdoor air samples were 253–1540 pg/m³ with a median of 555 pg/m³. The results of the gas-particle partitioning indicated that PBs had not reached equilibrium between the gas phase and particle phase. Concentrations of ∑₈PBs in the soil samples were EDI) was calculated. The EDI values (EDI_air + EDI_soil) for male adults, female adults and children were comparable, with mean values of 2.74 × 10⁻², 3.21 × 10⁻² and 2.70 × 10⁻² ng/kg-bw/day, respectively. All EDIs were much lower than the daily acceptable intake, indicating lower health risk with PB occurrence in outdoor environments. Finally, the total EDI from all external exposure routes (outdoor air, indoor air, soil, indoor dust, foodstuffs, pharmaceuticals and PCPs) was calculated for the first time. The total EDI was not consistent with that of the internal exposure, which provided new insight into future studies for human exposure assessment.