Function of NK-cells and neutrophils after radioiodine therapy in children and adolescents with differentiated thyroid cancer depending on the presence of metastases to lungs

The authors have revealed some peculiarities of cytotoxic activity of NK cells and metabolic activity of neutrophils under the effect of radioiodine therapy (RIT) in children and adolescents with differentiated thyroid cancer, which depended on the presence of metastases to lungs. A significant impairment of NK-cell function after RIT was established for both groups, but a more pronounced decrease in this index compared with the index before RIT was found for the group without metastases to lungs. The activity of neutrophils after RIT in patients without metastases to lungs was increasing, which is a response to irradiation. In the group with metastases to lungs after RIT index of neutrophils is not changed, what may be due to the depletion of the function