Solcoseryl as a powerful radio-protective compound

In adult inbred mice the blood extract Solcoserysup(R), when applied singly intraperitoneally or perorally is able to protect over acomparatively large dose range against γ-irradiation of a lethal dose whereby up to 100% survivors are obtained (as compared with practically no survival in the untreated, only irradiated animals of the control series). The effect of a low dose of Solcoseryl eliciting only approximately 50% survivors among the animals can be improved up to 100% if the animals were subject to heat adaptation for a period of 6 weeks prior to the Solcoseryl treatment and irradiation and heat adaptation continued during the subsequent observation time. (author)