Biomedical application of manganese dioxide nanomaterials

Manganese dioxide nanomaterial is a new type of inorganic nanomaterial offering numerous advantages: simple preparation, low cost, and environmental friendliness. This review summarizes the traditional and novel synthetic methods for manganese dioxide nanomaterials and mainly discusses their potential in biomedical applications. Manganese dioxide nanomaterials are mainly used as drug carriers in tumor therapy. In recent years, the construction of multifunctional nano-platforms using manganese dioxide has gradually improved. The main mechanism is that manganese dioxide nanomaterials can combine with reactive oxygen species in the tumor microenvironment to alleviate tumor hypoxia. Manganese dioxide has also been used to quench fluorescent carbon dots in fluorescent probes. Based on the oxidation ability and catalytic activity of MnO₂, MnO₂ nanosheets are widely used to build biosensors. New research shows that manganese dioxide nanomaterials also have great potential in gene therapy and nuclear magnetic imaging. (topical review)