Synthesis and radioprotective effects of organic salts of 2,2-dimethylthiazolidine and cystamine
- 1. Chinese Academy of Medical Sciences, TJ (China)
Description
Objective: To improve physical and chemical properties of 2,2-dimethylthiazolidine hydrochloride (DMTD) and enhance the anti-radiation effect. Methods: Various organic salts of 2,2-dimethylthiazolidine and cystamine were synthesized. The drug was administered to mice before 9.03 Gy 60Co gamma-ray whole body irradiation for evaluation of radioprotective effects. Results: Most of these compounds showed significant radioprotective effects. Among them, DMTD tartrate 250 mg/kg given i.p. 1 hour before irradiation increased the survival rate by 40%. Cystamine succinate 250 mg/kg administered i.p. 15 min. before irradiation increased the survival rate by 77.5%. Conclusion: Cystamine succinate showed marked anti-radiation effect. Further investigation is worthwhile
Additional details
Publishing Information
- Journal Title
- Chinese Journal of Radiological Medicine and Protection
- Journal Volume
- 17
- Journal Issue
- 4
- Journal Page Range
- p. 250-251.
- ISSN
- 0254-5098
- CODEN
- ZFYZDY
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 29001432
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- GAMMA RADIATION; MICE; ORGANIC ACIDS; RADIATION PROTECTION; RADIOPROTECTIVE SUBSTANCES; TARTRATES; THIAZOLES; WHOLE-BODY IRRADIATION
- Descriptors DEC
- ANIMALS; AZOLES; CARBOXYLIC ACID SALTS; DRUGS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; HETEROCYCLIC COMPOUNDS; IONIZING RADIATIONS; IRRADIATION; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIATIONS; RESPONSE MODIFYING FACTORS; RODENTS; VERTEBRATES