Published August 1975 | Version v1
Journal article Metadata-only

On the stability of a tin-phytate complex

Creators

  • 1. Tata Memorial Hospital, Bombay (India)
  • 2. Bhabha Atomic Research Centre, Bombay (India). Radiation Medicine Centre

Description

The stability of tin-phytate solution stored at room temperature has been studied. It was found that there is a pronounced increase in the rate of degradation of this complex, both temperature and phase change contributing to the enhanced rate of decomposition. The kidney uptake which is occasionally observed clinically with an aged tin-phytate complex labelled with sup(99m)Tc is probably due to an intermediate product which subsequently breaks down on further storage. Lyophilized tin-phytate complex 'kits' have a longer shelf life than the aqueous complex. (orig.)

Abstract (German)

Die Stabilitaet einer Zinn-Phytat-Loesung, die bei Raumtemperatur aufbewahrt wurde, wurde geprueft. Man fand, dass es eine ausgepraegte Verstaerkung der Zersetzung des Komplexes gibt, sowohl von der Temperatur her als auch von der Veraenderung der Phase her. Die Nierenaufnahme, die gelegentlich klinisch beobachtet wird, wenn aeltere Zinn-Phytat-Komplexloesungen, die mit sup(99m)Tc markiert werden, Verwendung finden, ist vermutlich auf ein Zwischenprodukt zurueckzufuehren, das seinerseits wieder zerfaellt, wenn die Loesung laenger stehen bleibt. Lyophilisierte Zinn-Phytat-Komplex 'Kits' haben eine laengere Lebensdauer als der waessrige Komplex. (orig.)

Additional details

Identifiers

DOI
10.1055/s-0038-1624910;

Publishing Information

Journal Title
Nuklearmedizin
Journal Volume
14
Journal Issue
03
Series
Nucl.-Med.
Journal Page Range
293-297
ISSN
0029-5566

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
7230816
Subject category
S60: APPLIED LIFE SCIENCES; S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
EQUILIBRIUM; IN VIVO; ISOMERIC NUCLEI; PHOSPHORUS COMPLEXES; PHYTIC ACID; RADIOPHARMACEUTICALS; RETICULOENDOTHELIAL SYSTEM; SCINTISCANNING; STABILITY; TECHNETIUM 99; TIN COMPLEXES
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COMPLEXES; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DRUGS; ESTERS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIPOTROPIC FACTORS; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; PHOSPHORIC ACID ESTERS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM ISOTOPES; TISSUES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
1 fig.; 1 tab.; 3 refs.; Updated automatically by Metadata and Full-Text Enrichment Agent