Published January 1980
| Version v1
Journal article
Comparioson of the effects of neutron and/or photon irradiation on spontaneous squamous-cell carcinoma in mice
Description
The effect of 30-MeV D+ → Be NIRS cyclotron neutrons on a spontaneous NR-S1 squamous-cell carcinoma was studied. The TD50 (number of tumor cells required for transplantation in half the sites) and tumor growth delay time (TGD) were determined. The RBE of 200-kVp x rays at the 10% survival level was 1.9 for aerobic cells and 2.0 for hypoxic cells; the OER at the same level was 1.7. Tumor cells irradiated with neutrons were unable to repair potentially lethal damage, in contrast to x-irradiated tumor cells. The RBE of 50-MeV D+ → Be neutrons was inversely related to deuteron energy for hypoxic cells. The relationship between TGD and peak skin reaction indicated no benefit from mixed beams or 5 neutron doses
Additional details
Publishing Information
- Journal Title
- Radiology
- Journal Volume
- 134
- Journal Issue
- 1
- Series
- Radiology.
- Journal Page Range
- 219-225
- ISSN
- 0033-8419
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 11570071
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; CARCINOMAS; DOSE-RESPONSE RELATIONSHIPS; EXPERIMENTAL DATA; FAST NEUTRONS; MICE; OXYGEN ENHANCEMENT RATIO; RBE; SURVIVAL TIME; TUMOR CELLS; X RADIATION
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BARYONS; BIOLOGICAL EFFECTS; DATA; DISEASES; ELECTROMAGNETIC RADIATION; ELEMENTARY PARTICLES; FERMIONS; HADRONS; INFORMATION; IONIZING RADIATIONS; MAMMALS; NEOPLASMS; NEUTRONS; NUCLEONS; NUMERICAL DATA; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES