An experimental study on the toxicity of several radionuclides inhaled at different doses
- 1. CEA Centre d'Etudes Nucleaires de Fontenay-aux-Roses, 92 (France). Dept. de Protection
- 2. Association Euratom-CEA, Centre d'Etudes Nucleaires de Fontenay-aux-Roses, 92 (France). Niveaux de Contamination Radioactive du Milieu Ambiant et de la Chaine Alimentaire
Description
For over 5 years investigations have been carried out on large lots of rats on the toxicological action of several inhaled radionuclides. Various physico chemical forms of α-emitting actinides and β-emitting lanthanides were used, respectively 239Pu, 238Pu, 241Am, as oxide or nitrate solution at pH1, 244Cm nitrate, and 144Ce chloride and 141Ce chloride and oxide. The activities deposited per gram of lung varied between 10nCi and 10μCi. The first effect observed was life-shortening. A comparison of the survival curves shows a heterogeneity factor whose values for the various radionuclides is given. Lung cancers were also observed. Rarely lung carcinomas were the cause of death, which was unknown and seemed to vary with the different compounds
Availability note (English)
MF available from INIS under the Report Number.Abstract (French)
On a rapporte les resultats de 5 annees d'etudes effectuees sur des lots de rats, concernant l'action toxicologique de quelques radionucleides inhales. On a utilise des formes physico-chimiques diverses d'actinides emetteurs α et de lanthanides emetteurs β, respectivement 239Pu, 238Pu, 241Am (oxyde ou nitrate) 244Cm (nitrate) et 144Ce (chlorure) et 141Ce (chlorure et oxyde). Les activites deposees par gramme du poumon variaient entre 10nCi et 10μCi. Le premier effet observe etait un raccourcissement de la vie. Une comparaison des courbes de survie a montre un facteur d'heterogeneite dont on a donne les valeurs pour les differents radionucleides utilises. On a egalement observe des cancers. Rarement ces cancers ont ete la cause de la mort, cause qui n'etait pas connue et semblait varier avec les differents composesFiles
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Additional details
Publishing Information
- Imprint Pagination
- 4 p.
- Report number
- CEA-CONF--3120
Conference
- Title
- 3. European congress of the International Radiation Protection Association. Criteria for radiation protection.
- Dates
- 13 May 1975.
- Place
- Amsterdam, Netherlands.
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 7233400
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- AMERICIUM 241; BIOLOGICAL RADIATION EFFECTS; CERIUM 141; CERIUM 144; CURIUM 244; INHALATION; LIFE SPAN; LUNGS; NEOPLASMS; PLUTONIUM 238; PLUTONIUM 239; RATS; TOXICITY
- Descriptors DEC
- ACTINIDE NUCLEI; ALPHA DECAY RADIOISOTOPES; AMERICIUM ISOTOPES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; CERIUM ISOTOPES; CURIUM ISOTOPES; DAYS LIVING RADIOISOTOPES; DISEASES; EVEN-EVEN NUCLEI; EVEN-ODD NUCLEI; HEAVY NUCLEI; INTAKE; INTERMEDIATE MASS NUCLEI; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PLUTONIUM ISOTOPES; RADIATION EFFECTS; RADIOISOTOPES; RARE EARTH NUCLEI; RESPIRATORY SYSTEM; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES