Final Report Summary: Radiation dosimetry of Cu-64-labeled radiotherapy agents using PET [Positron Emission Tomography]

This project began in 1996, and was completed in July 2001. The overall goals were to compare various methods of dosimetry of PET imaging agents, as well as develop more optimal methods. One of the major accomplishments of this grant was the human PET imaging studies of a positron-emitting radiopharmaceutical for somatostatin-receptor imaging, and subsequent dosimetry calculations resulting from this study. In addition, we collaborated with Darrell Fisher and Edmund Hui to develop a MIRD-hamster program for calculating hamster organ and tumor dosimetry in hamster models. Progress was made towards a point kernel approach to more accurately determining absorbed doses to normal organs, as well as towards co-registration of PET and MRI images. This report focuses on the progress made in the last 15 months of the grant, which in general is a summary of the progress over the 5 years the project was ongoing