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Published February 2023 | Version v1
Journal article Metadata-only

Bifunctional photoelectrochemical aptasensor based on heterostructured Ag3PO4/Ag/TiO2 nanorod array for determination of two tumor markers

Creators

  • 1. College of Geography and Environmental Sciences, College of Chemistry and Life Sciences, Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Zhejiang Normal University, Jinhua (China)
  • 2. Central Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua (China)

Description

Constructing of heterostructures can significantly improve the photoelectrical (PEC) response signal by promoting the migration and suppressing the recombination of photogenerated carries. A bifunctional PEC sensing platform was designed for simultaneous high-performance detection of mucin-1 (MUC1) and carcinoembryonic antigen (CEA), which was based on generated Z-scheme heterostructured Ag3PO4/Ag/TiO2 nanorod arrays (NAs) and enzyme-mediated catalytic precipitation by alkaline phosphatase (ALP) and Au/hollow Co3O4 polyhedron. The proposed aptasensor displayed linear ranges of 1.0–100 ng mL−1 and 0.1–50 ng mL−1 for MUC1 and CEA with limit of detections of 0.430 and 0.058 ng mL−1, respectively. This strategy offers potential applications for early diagnosis, monitoring progression, and even evaluating the prognosis of breast cancer in practice. Graphical

Additional details

Identifiers

URL
http://link.springer.com/openurl/fulltext?id=doi:10.1007/s00604-023-05654-w;
DOI
10.1007/s00604-023-05654-w;

Publishing Information

Journal Title
Microchimica Acta (Online)
Journal Volume
190
Journal Issue
3
Journal Page Range
p. 1-9
ISSN
1436-5073

INIS

Country of Publication
Austria
Country of Input or Organization
Austria
INIS RN
55057724
Subject category
S77: NANOSCIENCE AND NANOTECHNOLOGY; S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
Descriptors DEI
ALKALINE PHOSPHATASE; BIOLOGICAL MARKERS; CARCINOEMBRYONIC ANTIGEN; COBALT OXIDES; ELECTROCHEMISTRY; GOLD; NANOCHEMISTRY; NANOSTRUCTURES; NANOTECHNOLOGY; NEOPLASMS; OLIGONUCLEOTIDES; SILVER; SILVER PHOSPHATES; TITANIUM OXIDES
Descriptors DEC
ANTIGENS; CHALCOGENIDES; CHEMISTRY; COBALT COMPOUNDS; DISEASES; DNA; ELEMENTS; ENZYMES; ESTERASES; HYDROLASES; METALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; OXIDES; OXYGEN COMPOUNDS; PHOSPHATASES; PHOSPHATES; PHOSPHORUS COMPOUNDS; PROTEINS; SILVER COMPOUNDS; TITANIUM COMPOUNDS; TRANSITION ELEMENT COMPOUNDS; TRANSITION ELEMENTS

Optional Information

Copyright
Copyright (c) 2023 The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature