Published April 1988
| Version v1
Journal article
Encapsulation of interleukin-2 in murine erythrocytes and subsequent deposition in mice receiving a subcutaneous injection
Creators
- 1. Department of Agriculture, College Station, TX (USA)
Description
Radiolabeled recombinant human interleukin-2 (IL-2) was successfully encapsulated in both mouse and sheep erythrocytes. Of the added IL-2, 70% was recovered bound to or encapsulated within the carrier cells. Erythrocytes containing IL-2 were stable in vitro and most of the IL-2 remained associated with the cells following a 16-h incubation at 37 degrees C. When carrier erythrocytes containing IL-2 were injected subcutaneously into mice, intact [35S]IL-2 was detectable in a number of tissues 3 days after injection
Additional details
Publishing Information
- Journal Title
- Biotechnology and Applied Biochemistry
- Journal Volume
- 10
- Journal Issue
- 2
- Series
- Biotechnol. Appl. Biochem.
- Journal Page Range
- 183-190
- ISSN
- 0885-4513
- CODEN
- BABIE
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 20002530
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- ERYTHROCYTES; LYMPHOKINES; MICE; SUBCUTANEOUS INJECTION; SULFUR 35; TISSUE DISTRIBUTION; TRACER TECHNIQUES
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; EVEN-ODD NUCLEI; INJECTION; INTAKE; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; MAMMALS; MATERIALS; NUCLEI; RADIOISOTOPES; RODENTS; SULFUR ISOTOPES; VERTEBRATES