Gamma radiation sterilization of pharmaceutical active ingredients, adjuvants and packaging materials

Salts and esters of Benzylpenicillin, Phenoxymethylpenicillin, Neomycin Sulphate, Tobramycin Sulphate, Oxytetracycline Hydrochloride, S-carboxymethyl-l-cisteine, adjuvants, rubber-, alumina-, polyethylene-, polyvinylchloride- and glass-based packaging materials were treated with gamma radiation from 60Co gamma source. Most of the investigated materials proved to be stable to irradiation from pharmacopoeial aspect, except for change of colour. The accelerated stability tests and long-term storage showed no further change of the investigated parameters of the irradiated materials. (author)