Biological effects of heavy particles
- 1. National Inst. of Radiological Sciences, Chiba (Japan)
Description
A 18.5 MeV/amu helium-4 and 12 MeV/amu carbon and helium-3 ion beams produced by NIRS cyclotron were degraded by using a various thickness of alminum absorbers to obtain different quantities with LET (Linear Energy Transfer). The dose average LET was varied from 14.5 to 75 keV/μm with helium-4 and helium-3 beams and from 220 to 430 keV/μm with carbon beams. Then, Chinese hamster V79 cells attached to dishes were exposed without overlaying medium to single and mixed irradiations of these monoenergetic beams for a comparison with dose response survivals of cells for a given value of LET. Investigation was aimed to study a correlation between cell killing effect and dose average LET as well as a difference between single and mixed irradiations. These results might be useful for designing ridge filters and degraders to be used for heavy ion therapy. (author)
Additional details
Additional titles
- Subtitle (English)
- Cell inactivation and LET as a basis of therapy
Publishing Information
- Imprint Title
- Radiobiological scope of cancer therapy
- Imprint Pagination
- 237 p.
- Journal Page Range
- p. 143-150.
- Report number
- NIRS-M--75
Conference
- Title
- 20. NIRS symposium.
- Dates
- 8-9 Dec 1988.
- Place
- Chiba (Japan).
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 22046345
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; BRAGG CURVE; CARBON 12 BEAMS; HAMSTERS; HEAVY IONS; HELIUM 4 BEAMS; INACTIVATION; IRRADIATION; LET; RADIOBIOLOGY; RADIOTHERAPY; SURVIVAL CURVES
- Descriptors DEC
- ANIMALS; BEAMS; BIOLOGICAL EFFECTS; BIOLOGY; CHARGED PARTICLES; DIAGRAMS; ENERGY TRANSFER; INFORMATION; ION BEAMS; IONS; MAMMALS; MEDICINE; RADIATION EFFECTS; RODENTS; THERAPY; VERTEBRATES