An extrapolation of radionuclide retention data from mouse to man

Previous extrapolations of radionuclide retention data from animals to man have involved the use of data obtained from three to four animal species where each radionuclide was administered and a power function model was used to fit the data. A ''similarity ratio'' method has been developed whereby only data obtained from mice or rats could be used to extrapolate to humans so metabolic testing of many radionuclides in more than one species may be circumvented. Even though the focus of this paper is to provide a more cost-effective way to project radionuclide retention data from mouse to man, the rationale presented could result in a useful way to extrapolate other endpoint results in radiobiology. (author)