Evaluation of biochemical changes in experimental animals treated with some anticancer and radiosynthetizers

Cancer is the leading cause of mortality worldwide, and the failure of conventional chemotherapy to reduce the mortality rate indicates that new approaches are critically needed. The new and recent approaches of chemotherapy serve as an attractive alternative to control malignancy and the search for new therapeutic agents in this field has been prompted. The present work was designed to evaluate the in vitro anti-tumor effect of four novel quinoline derivatives with sulfonamide moieties against EAC cells. Also to test the efficacy of the most potent compound on other human cancer cell lines. The present study also planned to evaluate the radio synthesizing efficacy of the tested compound to γ-irradiation. The in vivo laboratory investigations have been focused on the effects of different treatments (chemotherapeutic, radio therapeutic and combination of both modalities on the changes in body weight gain, tumor weight and tumor volume. The effect of the different treatment modalities on histone de acetylase activity (HDAC), DNA fragmentation, apoptosis and distribution of cell cycle phases has been undertaken