Published May 1994 | Version v1
Journal article Metadata-only

Possible mechanisms of chromosomal aberrations: VII. Comparative dynamics of sister chromatid disjunction and realization of radiation-induced chromosomal aberrations during mitosis

Creators

  • 1. Institute of Cytology and Genetics, Novosibirsk (Russian Federation)

Description

An increase in radiation-induced chromosomal aberrations during c-metaphase sister chromatid disjunction was demonstrated in murine bone marrow cells exposed to a total γ-irradiation at 0.5 Gy. Caffeine (Cf) treatment during mitosis partially suppressed the chromatid disjunction rate and increased the number of radiation-induced aberrations in this mitosis. Nalidixic acid (NA) treatment of c-metaphase cells completely suppressed chromatid disjunction and the realization of induced aberrations. Topoisomerase 2 was assumed to be involved during mitosis in both processes

Additional details

Publishing Information

Journal Title
Russian Journal of Genetics
Journal Volume
30
Journal Issue
5
Journal Page Range
p. 573-576.
ISSN
1022-7954
CODEN
RJGEEQ

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
26032833
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Translation
Descriptors DEI
BIOLOGICAL PATHWAYS; CHROMOSOMAL ABERRATIONS; CHROMOSOMES; GAMMA RADIATION; GENETIC RADIATION EFFECTS; SISTER CHROMATID EXCHANGES
Descriptors DEC
BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; ELECTROMAGNETIC RADIATION; GENETIC EFFECTS; IONIZING RADIATIONS; MUTATIONS; RADIATION EFFECTS; RADIATIONS

Optional Information

Notes
Translated from Genetika; 30: No. 5, 644-648(1994).