Published April 1985 | Version v1
Journal article Metadata-only

Preparation, quality control and application of sup(99m)Tc-gluco-ene-diolate for renal scanning

Creators

  • 1. Nuclear Research Center, Baghdad (Iraq). Radioisotope Production Dept.

Description

A one-step freeze-dried Sn-glucose kit was developed to be labelled with technetium-99m. TLC, paper chromatography and gel chromatography column scanning techniques (GCS) were used for the determination of the labelling yield of the complex. High radiochemical purity was obtained (98%). In vivo distribution studies were performed in white rats. Maximum uptake in kidneys (28%) was achieved in 15-90 min. The blood disappearance curve studies of the labelled Sn(II)-gluco-ene-diolate in rabbits have shown two disappearance phases of activity from blood with biological half-times of 10 and 150 min for the fast and slow component respectively. (orig.)

Abstract (German)

Es wurde ein Einweg-Zinnglukose-Kit entwickelt, um mit Technetium-99m markiert zu werden. TLC, Papierchromatographie und Gel-Chromatographie-Saeulen-Scanning (GCS) wurden benutzt, um die Markierungsausbeuten des Komplexes zu bestimmen. Es wurde eine hohe radiochemische Reinheit erreicht (98%). In-vivo Verteilungsstudien wurden mit weissen Ratten durchgefuehrt. Nach 15-90 min wurde maximale Aufnahme in die Niere (28%) erreicht. Die Untersuchungen der Blutkonzentrationsabnahme-Kurven des markierten Zinn-2-Gluco-ene-dialat zeigten beim Kaninchen zwei Abnahmephasen der Aktivitaet mit biologischen Halbwertszeiten von 10 und 150 min fuer die schnelle bzw. langsame Komponente. (orig.)

Additional details

Publishing Information

Journal Title
Nuklearmedizin
Journal Volume
24
Journal Issue
2
Series
CODEN: NUKLD.;Nuklearmedizin.
Journal Page Range
93-95
ISSN
0029-5566

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
16067027
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
DISTRIBUTION; ISOMERIC NUCLEI; KIDNEYS; LABELLING; QUALITY CONTROL; RABBITS; RADIOMETRIC ANALYSIS; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; RATS; SCINTISCANNING; TECHNETIUM COMPLEXES; TECHNETIUM 99; TIME DEPENDENCE
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CHEMICAL ANALYSIS; COMPLEXES; CONTROL; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; QUANTITATIVE CHEMICAL ANALYSIS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RODENTS; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPLEXES; VERTEBRATES; YEARS LIVING RADIOISOTOPES