Biochemical investigations for interpretation of in vivo measurements of 32P-incorporation into irradiated or nonirradiated experimental tumors

In view of results of extracorporal measurements of the 32 P-incorporation into irradiated or nonirradiated tumors biochemical investigations of the 32P-incorporation have been performed, aiming at comprehension of the meaning and at clarification of the interpretability of these measurements. The results show that irradiation mostly decreases the content of 32P in nucleic acids. In principle, however, the latter is so low as compared to the total content of 32P, especially three hours after 32P-injection, that variations are hardly to be recorded by means of extracorporal measurements, particularly because they are superposed by changes in the 32P-content of other fractions. (orig.)