Three-dimensional conformal radiation therapy for 37 prostate carcinoma patients

Objective: To evaluate the outcome and prognosis of prostate carcinoma treated with three-dimensional conformal radiation therapy(3DCRT). Methods: From 2000 to 2004, 37 patients were so treated. Two patients have been lost to follow up. Twenty-four patients underwent orchiectomy before 3DCRT, 20 patients received chemotherapy combined with hormone therapy and 4 received radiation castration. All patients were treated with a median dose of 72 Gy(60-76 Gy), 2 Gy/f, 5 fractions/w. Results: With a median follow-up time of 27 months(6-107 months), the 3- and 5-year survival rate was 80% and 70%, respectively. Longrank analysis showed age, PSA level before treatment, lymph node metastasis, distant metastasis, total dose and combined modality were prognostic factors for the survival. Cox model multivariate analysis showed PSA level before treatment, total dose and combined modality were prognostic factors for the survival. Conclusions: The outcome of three-dimensional conformal radiation therapy for T2-T4 prostate carcinoma is safe and effective with tolerable side effects. PSA level before treatment, total dose and combined modality are prognostic factors for the survival. (authors)