Published April 2004 | Version v1
Journal article Metadata-only

Improving binding potential analysis in [11C]raclopride PET studies using cluster analysis

Creators

  • 1. Department of Nuclear Medicine, University of Ulm, 89070 Ulm (Germany)
  • 2. Department of Neurology, University of Ulm, 89070 Ulm (Germany)
  • 3. Redwood Neuroscience Institute, Menlo Park, California 94025 (United States)
  • 4. Department of Neuroinformatics, University of Ulm, 89070 Ulm (Germany)

Description

To calculate binding potentials (BP) in [11C]raclopride brain PET studies a reference tissue model is widely used. The aim of the present study was to improve the determination of time activity curves (TAC) of reference tissue regions using cluster analysis. In four patients with Huntington disease TACs of a cerebellar reference region were calculated either from manually placed circular ROIs within the cerebellum or by cluster analysis. BP estimates derived from cluster analysis are independent from inter- and intraobserver variations and show an improved reproducibility combined with a low variability compared to manually placed cerebellar ROIs. This is of high value in longitudinal studies

Additional details

Identifiers

DOI
10.1118/1.1668392;

Publishing Information

Journal Title
Medical Physics
Journal Volume
31
Journal Issue
4
Journal Page Range
p. 902-906
ISSN
0094-2405
CODEN
MPHYA6

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
36002611
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BRAIN; CARBON 11; CEREBELLUM; IMAGE PROCESSING; NERVOUS SYSTEM DISEASES; POSITRON COMPUTED TOMOGRAPHY
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; BRAIN; CARBON ISOTOPES; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; ISOTOPES; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; ORGANS; PROCESSING; RADIOISOTOPES; TOMOGRAPHY

Optional Information

Notes
(c) 2004 American Association of Physicists in Medicine.