Published 1992 | Version v1
Book Metadata-only

Dose-response analysis for boron neutron capture therapy of the B16 murine melanoma using p-boronophenylalanine

Creators

  • 1. Brookhaven National Lab., Upton, NY (United States)

Description

Boron Neutron Capture Therapy (BNCT) of a well-pigmented B16 melanoma implanted subcutaneously in the mouse thigh has been carried out at the Brookhaven Medical Research Reactor (BMRR) using the synthetic amino acid p-boronophenylalanine (BPA) as the boron delivery agent. The response of the B16 melanoma to BNCT was compared with the response to 250 kVp x-rays using both tumor growth delay and an in vivo/in vitro assay that measures clonogenic survival. These experiments allow a comparison of tumor growth delay, log cell kill and damage to normal tissues produced by BNCT or photon irradiation

Additional details

Publishing Information

Publisher
Plenum Press.
Imprint Place
New York, NY (United States)
Imprint Title
Progress in neutron capture therapy for cancer
Imprint Pagination
668 p.
Journal Page Range
p. 417-419.

Conference

Title
4. international symposium on neutron capture therapy for cancer.
Dates
4-7 Dec 1990.
Place
Sydney (Australia).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
24015346
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BORON COMPOUNDS; BORON 10; CELL KILLING; DOSE-RESPONSE RELATIONSHIPS; EXPERIMENTAL NEOPLASMS; MELANOMAS; MRR REACTOR; NEUTRON CAPTURE THERAPY; PHENYLALANINE; PHOTONS; UPTAKE
Descriptors DEC
AMINO ACIDS; AROMATICS; BORON ISOTOPES; BOSONS; CARBOXYLIC ACIDS; CARCINOMAS; DISEASES; ELEMENTARY PARTICLES; ENRICHED URANIUM REACTORS; EPITHELIOMAS; IRRADIATION REACTORS; ISOTOPE PRODUCTION REACTORS; ISOTOPES; LIGHT NUCLEI; MASSLESS PARTICLES; MEDICINE; NEOPLASMS; NEUTRON THERAPY; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOTHERAPY; REACTORS; RESEARCH AND TEST REACTORS; RESEARCH REACTORS; STABLE ISOTOPES; TANK TYPE REACTORS; THERAPY; THERMAL REACTORS; WATER COOLED REACTORS; WATER MODERATED REACTORS