Drug loading-release behaviour of mesoporous materials SBA-15 and CMK-3 using ibuprofen molecule as drug model

The well-ordered mesoporous silicate (SBA-15) was synthesized via soft-templating route using block copolymer P-123 as directing agent and tetraethoxysilane as the silica source. The ordered mesoporous carbon (CMK-3) was synthesized via a hard casting route using SBA- 15 as nano-template and sucrose as carbon source. The character of mesoporous structure of the samples was investigated by scanning electron microscopy, FTIR and element analysis. The loading release performance using SBA-15 and CMK-3 was investigated by ibuprofen molecule as the drug model. The results illustrated a unique trend of impregnation phenomenon from both of SBA-15 and CMK-3 which was closely related to the mesoporous structure of the materials. When the mesoporous carbon SBA-15 and CMK-3 were loaded by ibuprofen molecule, the agglomeration of ibuprofen did not appear on the outer surface of carbon with the increase of ibuprofen concentration. Our results indicated that mesoporous structure could influence the phase transformation behavior of ibuprofen, which can effectively decrease the drug release time of drug in delivery system. (paper)