Published December 1982 | Version v1
Journal article

Chemical quality control of [sup(99m)Tc] plasmin by affinityradiochromatography

  • 1. Central Hospital of Nordland, Bodoe (Norway)

Description

To establish a method for radiochemical quality control of [sup(99m)Tc]plasmin based on the knownaffinity of plasmin for lysine residues, human [113Sn]plasmin and [sup(99m)Tc]plasmin formed by different methods were analyzed in an affinityradiochromatographic system of lysine coupled to CNBr-activated sepharosis. From the observed immobilizations of the radioactivity when the plasmin was bound to the lysine-sepharosis, radiochemical purities of radiolabelled plasmin could be calculated. The effects of presence of Sn(II) and tartaric and gentisic acid and the remobilizations induced by 6-aminohexanoic acid were studied. (author)

Additional details

Publishing Information

Journal Title
Int. J. Appl. Radiat. Isot.
Journal Volume
33
Journal Issue
12
Series
Int. J. Appl. Radiat. Isot.
Journal Page Range
1409-1413
ISSN
0020-708X