Published December 2019 | Version v1
Journal article Metadata-only

Feasibility of a deep hyperthermia and radiotherapy programme for advanced tumors: first Spanish experience

Creators

  • 1. Dr. Negrin Hospital, Department of Radiation Oncology (Spain)
  • 2. Instituto Canario de Investigación del Cáncer (Spain)

Description

Background

Hyperthermia (HT) is used to increase the temperature of the tumor-sensitizing cells to the effects of radiation/chemotherapy. We aimed to assess the feasibility, tolerability and safety of hyperthermia treatment in a Radiation Oncology Department.

Methods

Between June 2015 and June 2017, 106 patients and a total of 159 tumor lesions were included in a prospective study (EudraCT 2018-001089-40) of HT concomitant with radiotherapy (RT). Systemic treatment was accepted. HT was given twice a week, 60 min per session, during RT treatment by a regional capacitive device (HY-DEEP 600WM system) at 13.56 MHz radiofrequency.

Results

Most lesions (138 cases, 86.8%) received all HT sessions planned. Thirteen lesions (12 patients) withdrew treatment due to grade ≥3 QMHT toxicity. All these 12 patients completed the prescribed radiotherapy and/or systemic treatment.

Conclusions

Regional hyperthermia is a feasible and safe technique to be used in combination with radiotherapy and systemic treatment.

Additional details

Identifiers

DOI
10.1007/s12094-019-02097-9;

Publishing Information

Journal Title
Clinical and Translational Oncology (Print)
Journal Volume
21
Journal Issue
12
Journal Page Range
p. 1771-1775
ISSN
1699-048X

INIS

Country of Publication
Spain
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
54103211
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CHEMOTHERAPY; HYPERTHERMIA; NEOPLASMS; PATIENTS; RADIOTHERAPY; RADIOWAVE RADIATION; SPAIN; TOXICITY
Descriptors DEC
BODY TEMPERATURE; DEVELOPING COUNTRIES; DISEASES; ELECTROMAGNETIC RADIATION; EUROPE; MEDICINE; NUCLEAR MEDICINE; RADIATIONS; RADIOLOGY; THERAPY; WESTERN EUROPE

Optional Information

Copyright
Copyright (c) 2019 Federaci#Latin Small Letter O With Acute#n de Sociedades Espa#Latin Small Letter N With Tilde#olas de Oncolog#Latin Small Letter I With Acute#a (FESEO)