Published July 1990 | Version v1
Journal article Metadata-only

A rapid and efficient synthesis of 2-deoxy-2-[18F]fluoro-acetamido-D-mannopyranose and -D-galactopyranose

Creators

  • 1. Tohoku Univ., Sendai (Japan). Research Inst. for Tuberculosis and Cancer
  • 2. Tohoku Univ., Sendai (Japan). Cyclotron and Radioisotope Center

Description

Rapid and efficient syntheses of 2-deoxy-2-[18F]fluoro-acetamido-D-mannopyranose (1) and -D-galactopyranose (2), respectively, starting from [18F]fluoride and ethyl bromoacetate are described. [18F]Fluoride was produced by the 18O (p, n) 18F nuclear reaction using the cyclotron. The total times required for synthesis of (1) and (2) are ca. 80 min. The radiochemical yield and purity of (1) are 18% and > 98% respectively. Compound (2) is also synthesized with the same radiochemical yield and purity. (author)

Additional details

Publishing Information

Journal Title
Journal of Labelled Compounds and Radiopharmaceuticals
Journal Volume
28
Journal Issue
7
Series
J. Labelled Compd. Radiopharm.
Journal Page Range
847-854
ISSN
0362-4803
CODEN
JLCRD

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
22007696
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
AMINES; CHEMICAL PREPARATION; FLUORINE 18; LABELLING; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; SACCHARIDES
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBOHYDRATES; COMPUTERIZED TOMOGRAPHY; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NANOSEC LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS; TOMOGRAPHY