Published March 5, 2022 | Version v1
Journal article Metadata-only

In Vivo Imaging of the Microglial Landscape After Whole Brain Radiation Therapy

Creators

  • 1. Department of Neuroscience, Center for Visual Science, Del Monte Neuroscience Institute, University of Rochester, Rochester, New York (United States)
  • 2. Department of Radiation Oncology, Center for Visual Science, Del Monte Neuroscience Institute, University of Rochester, Rochester, New York (United States)
  • 3. Department of Pediatrics, Del Monte Neuroscience Institute, University of Rochester, Rochester, New York (United States)
  • 4. Department of Neurology, Del Monte Neuroscience Institute, University of Rochester, Rochester, New York (United States)

Description

Whole brain radiation therapy (WBRT) is an important treatment for patients with multiple brain metastases, but can also cause cognitive deterioration. Microglia, the resident immune cells of the brain, promote a proinflammatory environment and likely contribute to cognitive decline after WBRT. To investigate the temporal dynamics of the microglial reaction in individual mice to WBRT, we developed a novel in vivo experimental model using cranial window implants and longitudinal imaging.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.ijrobp.2021.07.038

Additional details

Identifiers

DOI
10.1016/j.ijrobp.2021.07.038;
PII
S0360301621009081;

Publishing Information

Journal Title
International Journal of Radiation Oncology, Biology and Physics
Journal Volume
111
Journal Issue
4
Journal Page Range
p. 1066-1071
ISSN
0360-3016
CODEN
IOBPD3

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
53122311
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BRAIN; IMPLANTS; IN VIVO; METASTASES; MICE; PATIENTS; RADIOTHERAPY
Descriptors DEC
ANIMALS; BODY; CENTRAL NERVOUS SYSTEM; MAMMALS; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; RODENTS; THERAPY; VERTEBRATES

Optional Information

Copyright
Copyright (c) 2021 Elsevier Inc. All rights reserved.