Published 1977
| Version v1
Journal article
Radiochemical and radioimmunological quality studies of sup(99m)Tc-labelled human serum albumin produced by two commercial kits
- 1. Rijksuniversiteit Leiden (Netherlands). Div. of Nuclear Medicine
- 2. Rijksuniversiteit Leiden (Netherlands). Dept. of Pharmacology
Description
Technetium 99m-labelled human serum albumin may be prepared by means of an electrolytic reduction method or a reduction process using stannous chloride. Radiochemical analysis of both preparations reveal the presence of a particle-like component. Animal experiments prove that part of the preparation is rapidly cleared by the reticulo-endothelial system. Immunochemical tests demonstrate no loss of original antigenic properties of the sup(99m)Tc-labelled radiopharmaceutical. These phenomena suggest that labelled polymer of human serum albumin which behaves like a colloid, is present in the solution. (orig.)
Abstract (German)
Technetium-99-markiertes HSA kann mittels einer elektrolytischen Reduktionsmethode oder durch Reduktion mit Sn(II)-Chlorid hergestellt werden. Bei beiden Praeparationen lassen sich durch radiochemische Untersuchungen partikelartige Bestandteile feststellen. In Tierexperimenten konnte gezeigt werden, dass ein Teil der Praeparation vom retikuloendothelialen System schnell aufgenommen wird. Immunchemische Tests demonstrieren, dass die anfaenglichen antigenen Eigenschaften des Tc-99-markierten Radiopharmakums nicht verloren gehen. Diese Phaenomene lassen die Gegenwart eines markierten HSA-Polymers in der Loesung mit kolloidalen Eigenschaften vermuten. (orig.)Additional details
Publishing Information
- Journal Title
- Radiochim. Acta
- Journal Volume
- 24
- Journal Issue
- 4
- Series
- Radiochim. Acta.
- Journal Page Range
- 211-213
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 10437612
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ALBUMINS; BIOCHEMISTRY; CHEMICAL PROPERTIES; FILTRATION; POLYMERS; QUALITY CONTROL; RADIOIMMUNOASSAY; RADIOPHARMACEUTICALS; TECHNETIUM 99
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHEMISTRY; CONTROL; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SEPARATION PROCESSES; TECHNETIUM ISOTOPES; TRACER TECHNIQUES; YEARS LIVING RADIOISOTOPES