Investigation of the effect of gamma radiation on lincomycin

Sterilization of materials used in medical applications is necessary. Since the use of ethylene oxide will be forbidden in the next future and other sterilization methods as wet, and dry hot sterilization are not suitable for sterilization of drugs, further methods are needed which do not cause a significant decrease in the physical and chemical drug properties. Radiation sterilization can help in many cases. So Gamma or electron radiations were used for sterilization of antibiotics in the solid state as mentioned in the literature. Some antibiotics are already exposed to gamma or electron beam irradiation, and showed significant radiation resistance for low doses, but even small amounts of degradation products are not desirable