Quantitative analysis of lignans in Ginseng Schisandra Granules by HPLC

A simple and rapid analytical method for the quantitative determination of two lignans of Ginseng Schisandra Granules was developed. The determination was carried out on a Kromasil C₁₈ column (250 mm×4.6 mm, 5 μm)with mobile phase of acetonitrile-water(52:48). UV detection was performed at 218 nm, flow rate was 0.8 ml/min. The linear range of schizandrol A and schizandrol B were 16.03∼160.3 μg/mL, 5.26∼52.6 μg/mL, the mean recovery were 98.9%, 98.1%. The method is suitable for the quality control of Ginseng Schisandra Granules. (paper)