Published October 5, 2000
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Radio-marking and in vivo imagery of oligonucleotides
Description
This research thesis is part of activities aimed at the development of new molecules like oligonucleotides. Its first objective was the development and validation of a marking method with fluorine-18 of oligonucleotides for their in-vivo pharmacological assessment with positron emission tomography (PET). Further investigations addressed the use of iodine-125 for oligonucleotide marking purpose. This radio-marking, and in vivo and ex vivo imagery techniques are described, and their potential is highlighted for the pharmacological assessment of different oligonucleotides
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Additional details
Additional titles
- Original title (French)
- Radiomarquage et imagerie in vivo d'oligonucleotides
Publishing Information
- Imprint Pagination
- 243 p.
- Report number
- FRCEA-TH--3323
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 43054687
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BIOCHEMISTRY; BIOLOGICAL MARKERS; FLUORINE 18; IN VIVO; IODINE 125; NUCLEIC ACIDS; NUCLEOPROTEINS; OLIGONUCLEOTIDES; PHARMACOLOGY; RADIOPHARMACEUTICALS; TRACER TECHNIQUES
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CHEMISTRY; DAYS LIVING RADIOISOTOPES; DNA; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; NUCLEIC ACIDS; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPES
Optional Information
- Notes
- 192 refs.; Available from the INIS Liaison Officer for France, see the 'INIS contacts' section of the INIS website for current contact and E-mail addresses: http://www.iaea.org/INIS/INIS-contacts/