Synthesis and Characterization of Diranitidinecopper(II) Sulfate Dihydrate

The complex of ranitidine with Cu(II) has been synthesized in 1:2-mole ratio of metal to the ligand in water. The forming of the complex was indicated by shifting of maximum wavelength from 816 nm (CuSO₄·5H₂O) to 626 nm (the complex). Infrared spectra indicated NO₂ and NH functional group were coordinated to Cu(II). The percentage of copper in the complex measured by Atomic Absorption Spectroscopy (AAS) analysis was 7.5% indicating that formula of the complex was Cu(ranitidine)₂SO₄(H₂O)_n (n=2, 3 or 4). The electrical conductivity of Cu(II) complex in water was 71.0 Scm²mol^-1 corresponding to 1:1 electrolytes. Thermogravimetric/Differential Thermal Analysis (TG/DTA) showed the presence of two molecules of H₂O in the complex. UV-Vis spectra showed a transition peak on 15974 cm^-1 indicating square planar geometry. The complex was paramagnetic with µ_eff 1.77 BM. The proposed formula of the complex was [Cu(ranitidine)₂]SO₄·2H₂O. (paper)