Published December 2017 | Version v1
Journal article Metadata-only

DOTA-tetrazine probes with modified linkers for tumor pretargeting

Creators

  • 1. Department of Nuclear Medicine, Inselspital, Bern University Hospital and University of Bern, Freiburgstrasse, 3010 Bern (Switzerland)
  • 2. Department of Nuclear Medicine, Medical Center— University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetterstrasse 55, 79106 Freiburg (Germany)
  • 3. Philips Research, High Tech Campus 11, 5656 AE Eindhoven (Netherlands)
  • 4. Tagworks Pharmaceuticals BV, c/o Department of Nuclear Medicine and Radiology, Radboud University Medical Center, 6500 HB Nijmegen (Netherlands)
  • 5. SyMO-Chem BV, Den Dolech 2, 5612 AZ, Eindhoven (Netherlands)

Description

Pretargeted radioimmunoimaging and -therapy approaches building on the bioorthogonal inverse-electron-demand Diels–Alder (IEDDA) reaction between strained trans-cyclooctenes (TCO) and electron-deficient tetrazines (Tz) have yielded impressive results in recent years and have proven a vital alternative to biological pretargeting systems. After improvement of the TCO–antibody conjugates, we here report on our evaluation of a new series of radiolabeled Tz-probes.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.nucmedbio.2017.09.001

Additional details

Identifiers

DOI
10.1016/j.nucmedbio.2017.09.001;
PII
S0969805117301889;

Publishing Information

Journal Title
Nuclear Medicine and Biology
Journal Volume
55
Journal Page Range
p. 19-26
ISSN
0969-8051
CODEN
NMBIEO

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
51078417
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
DRUG DELIVERY; NEOPLASMS; PROBES; TETRAZOLES
Descriptors DEC
AZOLES; DISEASES; HETEROCYCLIC COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS

Optional Information

Copyright
Copyright (c) 2017 Elsevier Inc. All rights reserved.