Published March 2022 | Version v1
Journal article Metadata-only

Whole-body R2∗ mapping to quantify tissue iron in iron storage organs: reference values and a genotype

Creators

  • 1. Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald (Germany)
  • 2. Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital, Carl Gustav Carus University, TU Dresden, Dresden (Germany)
  • 3. Institute for Community Medicine, University Medicine Greifswald, Greifswald (Germany)
  • 4. Division of Data Science in Biomedicine, Peter L. Reichertz Institute for Medical Informatics, TU Braunschweig and Hannover Medical School, Brunswick (Germany)
  • 5. Research Group Computational Systems Medicine, TUM School of Life Sciences, Technical University of Munich, Freising-Weihenstephan (Germany)

Description

Highlights: • Whole-body R2∗ mapping is a simple approach to quantify tissue iron in iron storage organs. • Reference values of R2∗ are feasible to support the diagnosis of iron storage diseases. • Unspecific mutations in HFE SNPs appear not to affect the phenotype of tissue iron overload. To define reference values for the transverse relaxation rate (R2∗) in iron storage organs and to investigate the role of human haemochromatosis protein (HFE) genotype on iron storage.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.crad.2021.05.016

Additional details

Identifiers

DOI
10.1016/j.crad.2021.05.016;
PII
S0009926021002749;

Publishing Information

Journal Title
Clinical Radiology
Journal Volume
76
Journal Issue
11
Journal Page Range
p. 863.e11-863.e17
ISSN
0009-9260
CODEN
CLRAAG

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
53113165
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ANIMAL TISSUES; DIAGNOSIS; GENOTYPE; IRON; MUTATIONS; ORGANS; PHENOTYPE; PROTEINS; RELAXATION
Descriptors DEC
BODY; ELEMENTS; METALS; ORGANIC COMPOUNDS; TRANSITION ELEMENTS

Optional Information

Copyright
Copyright (c) 2021 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.