Published November 2001 | Version v1
Journal article Metadata-only

An experimental study of indirect labelling monoclonal antibodies with 99Tcm via 2-IT

Creators

  • 1. The Second Hospital Affiliated to Suzhou Univ., Suzhou (China)

Description

Objective: To label monoclonal antibodies (McAb) with 99Tcm via 2-IT. Methods: McAb was modified with 2-IT and labelled with 99Tcm-GH. The quantity of 2-IT and GH was studied. Results: The optimal reaction conditions were that 2-IT was in the range from 0.1 mg to 1 mg, GH 1 mg to 2 mg with more than 90% radiolabelling rate. Conclusion: The method of labelling McAb via 2-IT is simple and suitable for clinical use

Additional details

Publishing Information

Journal Title
Acta Academiae Medicinae Suzhou
Journal Volume
21
Journal Issue
6
Journal Page Range
p. 651-652
ISSN
1000-5749

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
33027487
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
CHEMICAL PREPARATION; CHEMICAL REACTION YIELD; LABELLED COMPOUNDS; LABELLING; MICE; MONOCLONAL ANTIBODIES; STABILITY; TECHNETIUM 99; TISSUE DISTRIBUTION
Descriptors DEC
ANIMALS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DISTRIBUTION; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; RADIOISOTOPES; RODENTS; SYNTHESIS; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; YIELDS