Published December 2017 | Version v1
Journal article Metadata-only

Human biodistribution and dosimetry of [18F]nifene, an α4β2* nicotinic acetylcholine receptor PET tracer

Creators

  • 1. Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin – Madison School of Medicine and Public Health, Madison, WI (United States)
  • 2. Department of Medical Physics, University of Wisconsin – Madison School of Medicine and Public Health, Madison, WI (United States)
  • 3. Departments of Radiology and Biomedical Imaging, Psychiatry, Yale School of Medicine, New Haven, CT (United States)
  • 4. Preclinical Imaging, Department of Radiological Sciences, University of California – Irvine, Irvine, CA (United States)
  • 5. Department of Medicine, University of Wisconsin – Madison School of Medicine and Public Health, Madison, WI (United States)

Description

The α4β2* nicotinic acetylcholine receptor (nAChR) system is implicated in many neuropsychiatric pathologies. [18F]Nifene is a positron emission tomography (PET) ligand that has shown promise for in vivo imaging of the α4β2* nAChR system in preclinical models and humans. This work establishes the radiation burden associated with [18F]nifene PET scans in humans.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.nucmedbio.2017.08.001

Additional details

Identifiers

DOI
10.1016/j.nucmedbio.2017.08.001;
PII
S096980511730241X;

Publishing Information

Journal Title
Nuclear Medicine and Biology
Journal Volume
55
Journal Page Range
p. 7-11
ISSN
0969-8051
CODEN
NMBIEO

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
51078419
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ACETYLCHOLINE; DOSIMETRY; FLUORINE 18; IN VIVO; POSITRON COMPUTED TOMOGRAPHY; RADIATION DOSES; RECEPTORS
Descriptors DEC
AMMONIUM COMPOUNDS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DOSES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; ESTERS; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MEMBRANE PROTEINS; NANOSECONDS LIVING RADIOISOTOPES; NEUROREGULATORS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; PARASYMPATHOMIMETICS; PROTEINS; QUATERNARY AMMONIUM COMPOUNDS; RADIOISOTOPES; TOMOGRAPHY

Optional Information

Copyright
Copyright (c) 2017 Elsevier Inc. All rights reserved.