Design for stimulation response drug dispatch system of precise release control function using soft graft by gamma-ray irradiation
Creators
- 1. National Inst. of Health Sciences, Tokyo (Japan)
Description
A micro spherical sharp of temperature response hydrogel was investigated basically for using as injection. Adjustment for micro-sphere of dextran was carried out using phase separation characteristics of the dextran and polyethylene glycol in aqueous solution. The particle diameter of the dextran micro-sphere was measured using a dynamic light scattering process. The particle diameter was at 1.5 μm on the average. Involvement rate of β-galactosidase in the dextran micro-sphere and it's release behavior were cleared. The β-galactosidase was released rapidly at an early time, and continued to release slowly. A temperature response polymer, poly-asparagic acid derivative was investigated also. The poly-asparagic acid derivative was indicated to loose the stability of β-galactosidase. (M. Suetake)
Additional details
Publishing Information
- Journal Title
- Kokuritsu Kikan Genshiryoku Shiken Kenkyu Seika Hokoku-Sho
- Journal Issue
- no.43
- Journal Page Range
- p. 73.1-73.3
- ISSN
- 0288-8874
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 36047212
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- ASPARAGINE; GALACTOSIDASE; GAMMA RADIATION; GRAFT POLYMERS; LIBERINS; MEDICAL SUPPLIES; METHACRYLIC ACID; MICROSPHERES; PARTICLE SIZE; TEMPERATURE DEPENDENCE
- Descriptors DEC
- AMIDES; AMINO ACIDS; CARBOXYLIC ACIDS; ELECTROMAGNETIC RADIATION; ENZYMES; GLYCOSYL HYDROLASES; HORMONES; HYDROLASES; IONIZING RADIATIONS; MONOCARBOXYLIC ACIDS; O-GLYCOSYL HYDROLASES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC POLYMERS; PEPTIDE HORMONES; PITUITARY HORMONES; POLYMERS; PROTEINS; RADIATIONS; SIZE
Optional Information
- Notes
- 1 ref., 3 figs.