Chronic irradiation and brain development. Progress report, February 15, 1976--February 15, 1977
Description
Tritiated water (3HOH) ingested by the female rats in the dose as low as 3 μCi/ml drinking water (69 μCi/day) produced highly significant decreases in body weight, cerebral weight, cerebral DNA (cell number), and cerebral protein, of the offspring at birth. These effects of such a low dose on fetal brain development were not demonstrated before. Administration of 3HOH before mating (and during pregnancy) seemed to be necessary for this damage; a disturbance of ovarian maturation is implicated. Chronic administration of 3HOH until birth of F2 generation did not result in more damage in F2 than in F1; high mortality and a selection of individuals less suceptible to radiation may be implicated
Availability note (English)
MF available from INIS under the Report Number; Available from NTIS., PC A01/MF A01.
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Additional details
Additional titles
- Augmented title (English)
- "3HOH ingestion by pregnant rats
Publishing Information
- Imprint Pagination
- 14 p.
- Report number
- UCLA--34P230X1
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 8324703
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Progress Report
- Descriptors DEI
- ACCLIMATION; BIOLOGICAL RADIATION EFFECTS; BRAIN; CELL PROLIFERATION; CHRONIC INTAKE; CHRONIC IRRADIATION; DNA; FERTILITY; FETUSES; INGESTION; LITTER SIZE; LOW DOSE IRRADIATION; MORTALITY; PREGNANCY; PROGENY; PROTEINS; RATS; TRITIUM OXIDES; WEIGHT
- Descriptors DEC
- ANIMALS; BIOLOGICAL EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; HYDROGEN COMPOUNDS; INTAKE; IRRADIATION; MAMMALS; NERVOUS SYSTEM; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIATION EFFECTS; RODENTS; TRITIUM COMPOUNDS; VERTEBRATES