Association of diurnal temperature range with daily mortality in England and Wales: A nationwide time-series study

Highlights: • A nationwide investigation of fourteen-year time-series data • A nonlinear DTR-mortality association was identified with distinct seasonal patterns. • Extremely high DTR increased short-term mortality, whereas extremely low DTR exhibited entirely different seasonal effects. • Mortality vulnerability to DTR extremes varied greatly by regional latitudes and climate conditions. • Findings are important for public health decision-making in coping with climate change. Diurnal temperature range (DTR) reflects within-day temperature variability and is closely associated with climate change. In comparison to temperature extremes, up-to-date DTR-health evidence at the regional and national scales has been still very limited worldwide, especially in Europe.