Development of 99Tcm-Q3 as a new type myocardial perfusion imaging agent

Objective: To develop 99Tcm -N,N'-ethylene-bis (acetylacetone iminato) bis [tris (3-methoxy-1-propyl) phosphine] (99Tcm-Q3) as a new type of myocardial perfusion imaging agent. Methods: After N,N'-ethylene-bis (acetylacetone iminato) and tris (3-methoxy-1-propyl) phosphine were made, N,N'-ethylene-bis (acetylacetone iminato) was labelled using reduced 99TcmO4- by SnCl2·2H2O under the presence of alkali, then tris (3-methoxy-1-propyl) phosphine was added and reacted for ten minutes, 99Tcm-Q3 was obtained at the end. Biodistribution in mice, in vitro stability and acute toxicity of 99Tcm-Q3 were examined. Results: 99Tcm-Q3 was taken up rapidly by the heart, and the uptake rate was very high, by 5 minutes post injection, 24.66% of the injected dose was taken up in per gram heart, and no significant washout was shown up by 4 hours. But 99Tcm-Q3 was cleaned out rapidly from blood, lung and liver. No poisonousness and adverse effects were observed, and its stability lasted more than 6 hours. Conclusions: 99Tcm-Q3 is a fairly good myocardial perfusion imaging agent for improving the quality of myocardial perfusion imaging