Published January 1987 | Version v1
Journal article Metadata-only

Studies on tumor necrosis factor (TNF): II. Metabolic fate and distribution of human recombinant TNF

Creators

  • 1. Univ. of Siena, Italy

Description

We have evaluated the fate of cold and 125I- human recombinant tumor necrosis factor (RTNF) using isolated organs such as rabbit and monkey livers and rabbit kidney and lungs. We have also evaluated the body distribution of the total radioactivity after iv administration of 125I-RTNF in the rabbits. Monkey and rabbit livers play little catabolic role for RTNF. Lungs do not catabolize TNF at all, while the kidney appears to be the main catabolic organ. Accordingly, the body distribution of 125I-RTNF shows that most of the radioactivity is concentrated in the kidneys

Additional details

Publishing Information

Journal Title
Lymphokine Res.
Journal Issue
no.1
Series
Lymphokine Res.
ISSN
0277-6766
CODEN
LYRED

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
18073183
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
CATABOLISM; INTRAVENOUS INJECTION; IODINE 125; KIDNEYS; LIVER; LUNGS; MONKEYS; PROTEINS; RABBITS; TISSUE DISTRIBUTION; TRACER TECHNIQUES
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; GLANDS; INJECTION; INTAKE; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; METABOLISM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PRIMATES; RADIOISOTOPES; RESPIRATORY SYSTEM; VERTEBRATES